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Out With The Old & In With The New – Brute Launches New Rebrand  – Brute Strength Training

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Out With The Old & In With The New – Brute Launches New Rebrand  – Brute Strength Training

FOR IMMEDIATE RELEASE,

Brute, previously recognized as Brute Strength Training, is thrilled to announce the launch of its new rebrand. This transformation marks a significant milestone for the company, and was the first priority of Matt Torres (CEO) and Micah Shoemaker (CMO) following their acquisition of the company in the second quarter of 2023. 

“We are really hype to introduce the world to our fresh rebrand because it embodies our commitment to our athletes, our unique approach of coaching, and our ability to create people-centered individualized programs,” said Matt Torres, CEO of Brute. “No matter where you are in your fitness or athletic journey, there is always an opportunity for growth; and that is precisely where we step in to help you with our remote coaching and our online training programs.”  

The rebrand introduces a new, vibrant color palette featuring green, pink, and black. These colors, accompanied with our new logo, showcase a more contemporary style along with our excitement for the future of the company and our athletes. “The new logo has a distinctive circular design that represents the stages of progression. When merged together, our logo creates a symbol of connection and growth,” explained Micah Shoemaker (CMO). The logo’s eye-catching aesthetics are deliberately crafted to show off the company’s energy. “We wanted a logo and a marque that showcases creativity and science just like our training programs,” said Micah. 

At the heart of our rebrand lies a compelling narrative that is “centered on utilizing our coaches individual creativity along with the science of our training methodologies to help bridge the gap between you and your goals. We want you to know that our coaches are by your side while you are pursuing the proudest version of yourself,” said Matt. 

Since 2013, Brute has been a dominant force in the professional sport of CrossFit and it does not show any signs of slowing down.For more information about the exciting new Brute, please visit our website here: www.brutestrengthtraining.com . 

About Brute:

Brute stands as a leading provider of coaching CrossFit professionals. Our dedicated coaches take pride in helping assist individuals in their fitness journey through our personalized training programs and individualized 1-1 coaching. We believe we can help you win through our people centered training approach. To learn more about our coaching style and training options please visit www.brutestrengthtraining.com 

Out With The Old & In With The New – Brute Launches New Rebrand  – Brute Strength Training

The Top 5 Best Home Saunas of 2024

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The Top 5 Best Home Saunas of 2024

Recovery from home has gotten a whole lot smarter over the years, and now more than ever we’re seeing general fitness enthusiasts add saunas to their home. From clearer and softer skin, to better sleep and reduced muscle or joint pain, adding sauna to your routine can come with a plethora of health benefits, the biggest being oxidative stress relief. 

Doctor of Physical Therapy, Dan Giordano, attributes the benefits to a Finnish study from the University of Eastern Finland, following sauna users over a 20-year span period. The study found that participants had a reduced risk of fatal cardiovascular events, with higher decreases correlated to higher average sauna sessions per week. Sauna use can also be linked to lowering blood pressure, decreased risk of Alzheimer’s disease and dementia along with lower risk of respiratory diseases. 

“Saunas have unwavering potential to increase overall health and longevity,” says Giordano. “The physical benefits are just the tip of the iceberg in terms of muscle and tissue recovery and strength benefits. What’s more impressive is the cognitive and cardiovascular benefits that are now being proven with consistent usage.” 

We broke down the top in-home saunas and why they could qualify for your recovery add-on: 

Made for committed athletes or those seeking at-home luxury wellness, the Sun Home Sauna comes with state of the art features and a full-spectrum heating system designed to elevate your heating experience. The Equinox ll contains high output heaters and wattage, including Halogen heaters known to raise temperatures at impressive speed. This product is supported by third-party testing, emitting only a 0.5mG- which beats out 95% of most common household devices in terms of safety measures. The best part? Making it a double with its 2-person seating. If you’re looking for luxury, safety and efficiency, start with Sun Home and bring your wellness journey to new heights. 

The Top 5 Best Home Saunas of 2024

Sun Home Equinox™ 2-Person Full-Spectrum Infrared Sauna

Before your scroll, hear us out. Golden Designs’ Modern Series is the definition of luxury. Made with all-natural Canadian Red Cedar interior finish, you’ll have year round aroma for your relaxation. This model is a flex product, constructed for both indoor and outdoor use, allowing you to be the master of design in terms of where you bring your home spa to life.  

Golden Designs Nora 2 Person Outdoor-Indoor PureTech™ Hybrid Full Spectrum Sauna

Golden Designs Nora 2 Person Outdoor-Indoor PureTech™ Hybrid Full Spectrum Sauna

A “fully-portable” insulated wet steam sauna sounds too good to be true, but Nurecover made it happen without hitting four figures in price point. With its insulated tent design, it makes for the perfect pop up alternative if you’re short on space. For less than $400 you get 7 heat levels, maxing out at 130 degrees, time settings up to 60-minutes and the option to get in red-light therapy, a recovery modality that’s been proven to decrease inflammation and promote circulation. 

Nurecover Tropic® Home Steam Sauna

Nurecover Tropic® Home Steam Sauna

Just when you think they’ve made it all- Ali Express brings the option to install your very own in-home spa. With both options of dry heat and wet steam, an added shower feature is included for cooling off and getting clean. Consider this for your next home or gym build. 

Ali Express Wet & Dry 2 person steam sauna room with shower

Ali Express Wet & Dry 2 person steam sauna room with shower

It’s no surprise that our pick for most aesthetically pleasing in-home sauna is also Goop-approved by Gwenyth Paltrow. The HigherDOSE infrared sauna has a charcoal gray exterior with a gorgeously lined wood interior. Though it’s more than a pretty face- it contains patented technology with low EMF carbon heaters, raising temperatures to some of the highest on the market within the category and contains chromotherapy lighting. 

HigherDOSE 3-Person Infrared Sauna

HigherDOSE 3-Person Infrared Sauna

Body Acne by Area Explained

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Body Acne by Area Explained

Dealing with body acne, regardless of age, can be a frustrating experience, especially when it appears in various places on the body. Like facial acne, body acne can be tied to several factors, ranging from a variety of lifestyle habits to environmental exposures. However, understanding body acne mapping and what’s behind your breakouts can help you pinpoint the underlying causes and how to treat each area more effectively.

What is acne body mapping, and how does it work?

Acne body mapping focuses on where acne appears on different parts of the body and figuring out why breakouts occur in these specific areas. Dermatologist Dr. Hannah Kopelman explains, “It’s similar to face mapping, but with body mapping, I often see the breakouts linked more to external factors like friction from clothing, sweat, or product buildup. While some internal factors like hormones or stress can play a role, body mapping tends to focus more on what’s happening outside the body, like your lifestyle and environment.”

What factors contribute to body acne?

While face acne is primarily triggered by internal factors, body acne is generally linked to external influences. However, some internal factors can still play a role. Some of the factors that contribute to body acne include:

Diet

Dietary choices can significantly impact how the skin reacts. For instance, a diet high in sugar and processed foods can lead to inflammation, often resulting in acne. Following a diet rich in fruits, vegetables, lean proteins, and whole grains can improve your skin’s condition, reduce inflammation, and heal your body overall.

Hormones

Hormonal fluctuations—such as those caused by menstruation, pregnancy, puberty, or stress—can trigger body acne. Fluctuations often lead to an increase in the production of sebum, clogging pores and causing breakouts.

Clothing

Body Acne by Area ExplainedBody Acne by Area Explained

Wearing tight or non-breathable clothing can trap sweat and bacteria against the skin, creating a breeding ground for acne. Items like sports bras, gym gear, or tight-fitting clothes can cause or worsen this condition if not changed and washed frequently.

Hygiene

Hygiene is one of the most critical factors that often determines your acne. Simple habits like not showering after a workout or wearing dirty clothing can lead to clogged pores, resulting in breakouts. It’s essential to clean your skin regularly, especially after sweating.

Environment

Humidity, pollution, and exposure to toxins can all increase the likelihood of body acne. Sweating in hot or polluted environments without washing your skin thoroughly can exacerbate the problem.

Chemicals and Other Toxic Ingredients

Skincare products, lotions, or even laundry detergents containing harsh chemicals can irritate the skin, causing breakouts. Gentle and hypoallergenic products are best to minimize breakouts in these situations.

Acne on different parts of your body: What does it mean?

Each area of the body can provide clues to what’s causing your acne based on the different causes found and how you can treat them going forward.

Scalp

Causes:

Scalp acne is often triggered by a combination of factors, such as not washing your hair frequently enough or skipping a wash after sweating, which can lead to the buildup of oil and bacteria. Irritation from certain hair products containing harsh chemicals can also clog pores and cause breakouts, especially if you use heavy hair oils that trap dirt. Additionally, wearing dirty hats or hair accessories can introduce bacteria to your scalp, worsening acne. 

Treatments:

While you don’t want to over-wash your hair, try aiming for at least two or three times a week and always after sweating. Also, opt for gentle, sensitive hair products like dandruff shampoo, and steer clear of using oils on the scalp as this can clog pores. Don’t forget to regularly wash your hats, headbands, and other accessories to keep the bacteria at bay.

Neck

Causes:

Neck acne can be caused by several factors, including using certain makeup products and dirty brushes, which can transfer bacteria to your skin. Hair products, oils, and perfumes that rub against the neck can also clog pores, and shaving irritation or harsh shaving products can trigger breakouts. Tight clothing like turtlenecks and collared shirts can also trap sweat and bacteria, particularly if you don’t shower after sweating, such as after a workout. 

Treatments:

To treat and prevent neck acne, try wearing your hair up to keep hair products off your neck, and avoid using comedogenic products or perfumes that could irritate your skin. Washing your clothing in hypoallergenic detergents can also reduce irritation that may transfer from your clothing. Most importantly, be sure to include your neck in your skincare routine. Especially for those who blend their makeup into their neck, cleansing the neck should be as thorough as the face.

Chest

body acne body acne

Causes:

Acne on the chest is often caused by hormonal imbalances and stress, which can lead to increased oil production and clogged pores. The buildup of sweat, oil, and bacteria, especially after exercise, can further aggravate the skin and wearing tight clothing without changing after sweating traps these irritants against the skin. Poor diet, food sensitivities, and allergic reactions also play a big role in chest acne and should be monitored carefully if you notice an increase in breakouts.

Treatments:

To treat and prevent chest acne, it’s essential to shower after sweating and avoid using heavy perfumes or lotions that can clog pores. Wearing breathable, loose-fitting clothing can also help the skin stay cool and dry. Following a well-balanced diet while managing stress levels can also help balance hormones, especially during PMS. HUMs Hormone Balance uses estrogen to provide support in balancing symptoms during PMS like cramps, mood swings, and irritability. It can also help balance the fluctuation in mood and keep hormonal acne under control. If you are prone to rough PMS symptoms or experience worse-than-normal acne, this supplement may be just what you need.

Back/Shoulders

Causes:

Back and shoulder acne can be triggered by several factors, including wearing tight clothing or sports bras, which can trap sweat and bacteria, particularly under bra straps where acne is common. Wearing unwashed workout gear further aggravates the problem by allowing bacteria to build up on the skin. Additionally, harsh hair or laundry products can irritate the skin, leading to breakouts. 

Treatments:

While most typically shower once a day, those who work out or have demanding jobs where they might get sweaty and dirty should shower immediately after to clear their skin from dirt, oil, and bacteria. As far as what products to use in the shower, Kopelman recommends products with ingredients like salicylic acid, benzoyl peroxide, or tea tree oil, as they help target acne by unclogging pores and reducing inflammation. Exfoliating body washes are safe to use, but don’t use them every day as they can be irritating. While washing your body is a no-brainer, don’t forget that your workout gear also gets dirty and needs cleaning regularly, too.

Arms

Causes:

Acne on the arms is often caused by excess oil production, which can clog pores and lead to breakouts. Irritating lotions or laundry products that leave residue on the skin can further exacerbate the problem while wearing tight clothing can trap oil and bacteria against the skin. 

Treatments:

To manage arm acne, it’s helpful to use acne-specific body washes and exfoliate or dry brush a few times a week to remove dead skin cells and prevent pore blockages. For stubborn spots, salicylic acid or benzoyl peroxide can be used to target specific breakouts. Choosing non-comedogenic hypoallergenic products can also help reduce irritation.

Pubic Area/Booty

Causes:

Acne in the pubic area and on the booty is often caused by wearing tight-fitting clothing (e.g. leggings) or non-breathable underwear, which can trap moisture and create the perfect place for bacteria to grow. Shaving in an area with sensitive skin can often lead to irritation and breakouts, while using scented products (such as for hair removal) can disrupt the delicate pH balance of the vaginal area, causing further issues. 

Treatments:

To prevent and treat acne in these sensitive areas, it’s important to shower after sweating and put on clean, breathable cotton underwear to allow air circulation. Going without underwear at night can be a great way to let the skin breathe. As for products, using a pH-balanced cleanser or an unscented, hypoallergenic soap are the best choices and can avoid pH disruption. Still, taking other measures when removing hair can be beneficial. Kopelman says you can also “gently exfoliate a day or two after shaving to help prevent ingrown hairs.” Just make sure not to over-exfoliate, or you may further irritate the skin.

Thighs/Legs

Causes:

Many variables can trigger acne on the thighs and legs. Irritating soaps, lotions, or laundry products can cause inflammation and clog pores. Tight clothing can also trap sweat and bacteria against the skin, while ingrown hairs from shaving or waxing only further aggravate the issue by blocking hair follicles. 

Treatments:

To manage acne in these areas, switch to hypoallergenic products that are gentle on the skin and wear looser, breathable clothing to reduce irritation. Regular exfoliation can help clear away dead skin cells and prevent clogged pores from occurring, while gentler shaving techniques can minimize the occurrence of ingrown hairs, reducing breakouts. Kopelman says, “After-shave or other soothing products can really help if you’re dealing with irritation, razor burn, or ingrown hairs from shaving.” She suggests looking for products with ingredients like aloe vera, witch hazel, or chamomile, which can all help calm the skin and reduce inflammation. 

Spot Treatments:

For some, acne can randomly appear in just one or two spots rather than a cluster or breakouts. Several ingredients and products can be applied directly to acne spots to reduce redness and inflammation, ultimately speeding up the healing process. Here are a few ingredients that Kopelman recommends for spot treatments:


Salicylic Acid: A beta hydroxy acid (BHA), which helps exfoliate the skin, reduce inflammation, and unclog pores

Benzoyl Peroxide: Kills acne-causing bacteria and reduces inflammation

Sulfur: Dries out active blemishes and reduces redness

Tea Tree Oil: Has antimicrobial properties, killing acne-causing bacteria. It also dries out the skin and reduces inflammation. (This is a good, natural option; however, Kopelman warns that it may irritate some people, so make sure to patch-test it first.)

HUM’s Skin Squad: Our unique formula that helps combat acne. This potent probiotic for clear skin contains 9 strains for non-cystic acne plus prebiotic konjac root for balanced gut health. It is a must-have supplement for your acne fight!

Pimple patches are another convenient option to use that contain many of the same (or similar) ingredients and are easy to apply, making them a favorite go-to for acne healing. “Spot treatments can be really effective,” she says, “but remember to use them sparingly—applying them to larger areas can dry out and irritate your skin.”

The Body Acne Mapping Takeaway

Understanding body acne mapping and how different parts of the body can be affected by specific factors is the key to treating and managing breakouts. The best way to achieve this is to be observant of where acne is showing up on your body and based on some of the potential factors, make small changes one by one. This will help you determine which lifestyle habits may be causing more harm than good. From here, you can take control and clear your skin from head to toe. This isn’t to say that you won’t get the occasional breakout from a sweaty workout or an ingrown from shaving, but with consistent changes, these occurrences should be minimal.

Travel Fitness Guide: Master TRX Workouts

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Travel Fitness Guide: Master TRX Workouts

You have undoubtedly come across TRX if you have researched some basic workout equipment to exercise at home or on the road.

But what exactly is it, how does it work, and can it be a viable alternative to gym training for muscle gain, fat loss, and overall athleticism?

Read on because we are breaking it all down for you today.

What is TRX, and How Does It Work?

TRX, also known as total resistance exercise, is a suspension kit created by former US Navy SEAL Randy Hetrick.

He came up with the idea for the TRX while deployed in Asia and stuck doing endless push-ups to stay in shape.

While there, he created the first iteration of the TRX from parachute webbings and a jiu-jitsu belt. He used it to train his whole body in a more balanced way without needing access to a fully loaded gym.

Travel Fitness Guide: Master TRX Workouts

Of course, that version of the TRX is unrecognizable and far from what we know today. But, his initial idea paved the way for arguably the most popular suspension kit beloved by many fitness enthusiasts.

The way TRX works is straightforward. You anchor the TRX kit (typically overhead; we will talk more about that below) and use your body weight against the force of gravity to train the desired muscles.

Despite the simplicity, you can pick from dozens of effective exercises and variations that fit your current abilities and push you just beyond the borders of your comfort zone. While seemingly difficult to use, the beauty of TRX is that it is great for trainees of all levels – beginners and advanced alike.

Can you build Muscle and lose Fat with TRX?

If you are new to fitness or come from a background in weight training, using a suspension kit might not seem like an effective way to build muscle or lose weight. However, the truth is that TRX is effective for both objectives.

First, for muscles to grow, they need to be subjected to increasingly more tension, which you can do with TRX. As mentioned, you can adjust the difficulty of exercises to increase the training stress and force your muscles to adapt by getting bigger and stronger.

Second, fat loss primarily comes down to your diet because the age-old saying, “You cannot out-train a bad diet.” is true. Simply put, it is far easier not to eat 1,000 calories than to burn them through physical activity.

TRX can be a valuable addition to a fat loss plan because it provides a muscle stimulus, allowing you to retain more lean mass while dieting. As a result, you can lose more fat and achieve a lean and athletic physique.

5 Impressive Benefits of TRX

1. Ideal For Full Body Training

Unlike simple exercises targeting one or two muscles around a single joint, TRX typically engages your entire body.

Even if you aim to train a specific muscle (e.g., the biceps), multiple others must assist by contracting to keep you in position while doing your reps.

This means you can more effectively train your whole body without needing to do as many exercises.

2. It Builds Strength and Improves Balance

To continue the discussion from the previous point, TRX exercises are generally more challenging and involve the entire body. Even if you primarily target one area, other muscles assist in keeping you stable and in position.

This means that, while doing a movement to strengthen your upper back (e.g., inverted rows), biceps (e.g., bodyweight curls), chest (e.g., flyes), or quadriceps (e.g., Bulgarian split squats), other muscles also work hard to keep you in position.

The advantage here is that this builds whole-body strength and improves your balance.

3. You Can Use it to Train Almost Anywhere

We are firm believers in simple and practical solutions, especially while traveling. Having access to a full gym, even on the road, is fantastic, but it may not always be possible.

The great thing about TRX and similar tools is they allow you to have a solid workout almost anywhere. Whether in a hotel room, at home, outside, or in a small and bare hotel gym, you can use the suspension kit to challenge yourself and get closer to your goals.

A growing number of hotels now incorporate TRX equipment into their gym facilities, reflecting a trend we are excited to see. For travelers interested in maintaining their TRX workout routines while on the road, HotelGyms.com allows users to easily search for and discover hotels that provide the specific gym facilities they prefer, including those equipped with TRX equipment.

4. It is Customizable Based on Fitness Levels

Using a suspension kit to exercise might seem like a bad idea if you are a beginner because some movements can be intimidating. But do you know what?

An overlooked TRX benefit is that you can adjust the difficulty of most movements to fit your current abilities. We will go over five ways to do that below.

5. It is Light, Portable, and Affordable

To top it off, TRX is affordable, which makes it a great fitness solution if you are on a budget.

Instead of spending hundreds or thousands of dollars on expensive equipment (which you cannot even take on the road), TRX provides everything you need.

It is also light and compact, which makes it the perfect companion for your travels, along with some other portable fitness equipment.

How to Use TRX On The Road

Get the Right App

The first step is to download a workout app to pair with your TRX kit. One option is the official TRX app, which offers workout plans, live classes, and exercise instructions. This is good if you are relatively new to working out and are unsure how to structure workout plans and what to do.

Another option is to download Fitbod. This interactive app generates workout plans based on fitness level, goals, and, yes, even available equipment.

Its exercise library features TRX exercises. So, when you select the TRX kit as part of your equipment during the setup process, it will automatically generate a workout plan with TRX exercises, such as TRX glute bridges and TRX chest flyes.

However, if you are more experienced and prefer to write workout programs, you can use Hevy. Its exercise library does not have all the TRX movements, but they are enough to get started.

You can add movements to your routine (and even create custom TRX exercises), log your workouts (exercises, sets, reps, weight lifted, and RPEs), and track your performance over time.

Start Your Workout

As noted several times, the beauty of TRX lies in its simplicity and ease of use. Though it may seem complex, you only need a door anchor or strap, which would allow you to use the kit in your hotel room, outside, or at a hotel gym. You get both of these along with your TRX kit.

First, there is the door anchor, which you secure against the top of a door. Attach your TRX kit for a stable foundation to do your favorite movements.

TRX Workout in Hotel Room

You can also use this in a hotel room because the square part that goes behind the door is covered in soft fabric, so it does not scratch or otherwise damage the door.

Second, you have a TRX strap (also known as a suspension anchor), which you can tie over an object (e.g., a tree trunk, tree branch, or a pull-up bar) and secure in position with the carabiner at the end. Then, simply attach your TRX kit via the carabiner, and you are good to go.

3 Ways to Adjust the Difficulty of Your TRX Workouts

1. Adjust Your Body’s Angle

Let’s say you have set up the TRX kit, but the exercises you want to try feel too challenging (or not difficult enough).

The first and most practical thing you can do is adjust your body’s angle. Doing so instantly changes the difficulty of movements because it allows you to lift more or less of your total body weight.

Take the inverted row as an example. The more upright you are, the less of yourself you have to pull, making the exercise more beginner-friendly. In contrast, leaning back and stepping forward makes you more horizontal, forcing you to pull a larger percentage of your body weight.

TRX works perfectly for this because it comes with adjustable straps, allowing you to lengthen and shorten it to fit your needs.

2. Vary the Range of Motion

Another way to change the difficulty of each rep is to increase or decrease the range of motion.

For example, if you are doing a chest press. The more you lower yourself (causing your arms to bend and your elbow to travel to your sides and behind your torso), the more challenging each rep will be.

If you lack the strength to perform the movement through such a range of motion, lower yourself to a smaller degree–for example, to the point where your elbows are almost to your sides.

You can apply this to any other TRX exercises you try, be it a squat, lunge, inverted row, or bicep curl.

3. Do Circuits

Circuit training is about doing multiple exercises (typically for different muscles) back-to-back with little to no rest in between. This can be a great way to save time and give your cardiovascular system a good workout.

You can do only TRX exercises, like so:

TRX squat ⇒ TRX inverted row ⇒ TRX chest press ⇒ TRX bicep curl ⇒ TRX tricep extension ⇒ Recovery

Or combine TRX with equipment-free activities, like so:

Bodyweight squat ⇒ TRX inverted row ⇒ Push-up ⇒ TRX bicep curl ⇒ Chair dips ⇒ Recovery

Our Verdict on TRX

A TRX kit is an invaluable addition to your fitness arsenal. Affordable, incredibly versatile, compact, and easy to transport, it ensures your workouts remain consistent, whether at home, outdoors, or on the move.

Eager to enhance your travel fitness experience? Do not let travel interrupt your fitness regimen. With our unique GymFactor, you can find the perfect hotel equipped with superior gym facilities, specifically matched to your fitness requirements. Initiate your search today and guarantee your next travel destination supports your fitness objectives. Explore HotelGyms.com now to locate your ideal fitness-focused accommodation!

FAQs

Is TRX suitable for beginners?

TRX works for beginners because there are plenty of movements suitable for newbies, and certain modifications can make each repetition less challenging.

Can I take my TRX kit outdoors?

TRX kits come with a strap (suspension anchor) to tie around objects, such as pull-up bars, trees, and even tree branches, to enjoy refreshing workouts outside.

Is TRX safe?

So long as you secure it as outlined in the instructions and do exercises you can handle, TRX is quite safe.

Research Points to Potential New Treatment for Aggressive Prostate Cancer Subtype

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Research Points to Potential New Treatment for Aggressive Prostate Cancer Subtype

Research Points to Potential New Treatment for Aggressive Prostate Cancer Subtype

 

By Nicole Fawcett

When researchers at the University of Michigan Rogel Cancer Center first identified a new subtype of aggressive prostate cancer, they knew they needed to understand how this genetic alteration was driving cancer and how to target it with treatment.

In two new papers, both published in Cell Reports Medicine, they do both, describing the mechanisms of how alterations in the CDK12 gene drive prostate cancer development and reporting on a promising degrader that targets CDK12 and a related gene to destroy tumors.

Researchers previously found loss of the CDK12 gene in about 7% of patients with metastatic prostate cancer, suggesting this alteration may be linked to a more-aggressive form of the disease. This was discovered from DNA and RNA sequencing from patient tumor samples. CDK12 also plays a role in some ovarian cancers.

To understand how CDK12 loss impacts cells on a molecular level, researchers created a mouse model to try to parallel the genetic alterations they were seeing in human prostate cancers.

“What was quite surprising was when we created CDK12 loss in a mouse prostate, this caused precursor lesions to form in the mouse prostate. Then, when we added loss of the p53 oncogene, the mice developed bona fide invasive prostate cancer,” said senior author Arul M. Chinnaiyan, M.D., Ph.D., director of the Michigan Center for Translational Pathology and S.P. Hicks Professor of Pathology at Michigan Medicine. “It will be an addition to the field to have a genetically engineered mouse model that parallels what we see in human prostate cancer.”

With the mouse model, researchers then discovered the mechanism of how CDK12 loss induces DNA damage. The loss of this gene activates other known cancer driver genes, causing them to be overexpressed at a high level while also causing DNA to be replicated very rapidly. The collision of these two processes leads to DNA damage.

“These back-to-back studies taken together are quite impressive. We created an animal model and then deciphered the mechanisms of how CDK12 loss actually drives prostate cancer,” Chinnaiyan said.

The team also found that a partner gene, CDK13, is important in targeting the alteration therapeutically. They developed a potential therapy designed to degrade CDK12 and CDK13. Testing in cell lines and mice showed the degrader specifically binds to CDK12 and CDK13 and stops the growth of cancer cells over normal cells. The degrader can be absorbed orally and would not need to be delivered intravenously. This is notable as most protein degraders are too large to be absorbed orally, which has limited their potential in drug development.

Further, they found that knocking down CDK12/13 activated the AKT pathway, which plays a role in cancer development. Combining the CDK12/13 degrader with existing therapies targeting AKT resulted in a synergistic effect in destroying cancer cells. This suggests the potential to combine a CDK12/13 degrader with other approved therapies.

“It’s well known that single therapies for cancer treatment have been challenging. Oftentimes patients develop resistance. If we can find the right combination, we could prevent resistance mechanisms from occurring. That’s one of the benefits of finding an FDA-approved agent to combine with CDK12/13 degraders,” Chinnaiyan said. “This study also highlights an international collaboration with Ke Ding, Ph.D., a medicinal chemist at the Shanghai Institute of Chemistry, in the development of orally bioavailable CDK12/13 degraders.”

Researchers plan to further develop the CDK12/13 degrader with a goal of moving it to a clinical trial.

Note for patients: This work is preclinical and more research is needed. A CDK12/13 degrader is not currently available in clinical trials. For information on current clinical trials or questions about prostate cancer treatment, call the Michigan Medicine Cancer AnswerLine at 800-865-1125 or visit www.rogelcancercenter.org/clinical-trials.

Additional authors: Jean Ching-Yi Tien, Jie Luo, Yu Chang, Yuping Zhang, Yunhui Cheng, Xiaoju Wang, Jianzhang Yang, Rahul Mannan, Somnath Mahapatra, Palak Shah, Xiao-Ming Wang, Abigail J. Todd, Sanjana Eyunni, Caleb Cheng, Ryan J. Rebernick, Lanbo Xiao, Yi Bao, James Neiswender, Rachel Brough, Stephen J. Pettitt, Xuhong Cao, Stephanie J. Miner, Licheng Zhou, Yi-Mi Wu, Estefania Labanca, Yuzhuo Wang, Abhijit Parolia, Marcin Cieslik, Dan R. Robinson, Zhen Wang, Felix Y. Feng, Jonathan Chou, Christopher J. Lord, Gabriel Cruz, Josh N. Vo, Brian Magnuson, Somnath Mahapatra, Hanbyul Cho, Saravana Mohan Dhanasekaran, Cynthia Wang, Kaijie Zhou, Yang Zhou, Pujuan Zhang, Weixue Huang, Rudana Hamadeh, Fengyun Su, Rui Wang, Stephanie J. Miner, Rohit Mehra, Ke Ding

Funding for this work is from Prostate Cancer Foundation, National Cancer Institute (grants P50-CA186786, U2C-CA271854, R35-CA231996), National Natural Science Foundation of China, Cancer Research UK, Department of Defense, Ministry of Science and Technology of China, Howard Hughes Medical Institute, A. Alfred Taubman Medical Research Institute, American Cancer Society

Disclosure: The University of Michigan and the Shanghai Institute of Organic Chemistry have filed patents on the CDK12/13 degraders and inhibitors mentioned in these papers. Chinnaiyan, Ding, X. Wang, J. Yang, Y. Chang and Tien have been named as co-inventors on these patents.

Papers cited: “Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition,” Cell Reports Medicine. DOI: 10.1016/j.xcrm.2024.101752

“CDK loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13,” Cell Reports Medicine. DOI: 10.1016/j.xcrm.2024.101758

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Previously Published on michiganmedicine.org with Creative Commons License

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2024 Olympia Weekend Kicks Off With Annual Press Conference

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2024 Olympia Weekend Kicks Off With Annual Press Conference

After months of buildup, promotion, and anticipation, bodybuilding’s biggest weekend has arrived. The 60th Olympia has begun at Resorts World in Las Vegas, NV, and the festivities began with the traditional Olympia 2024 press conference.

Over 1,500 fans packed the room, leaving many having to stand as they hear champions and top challengers from all 11 pro divisions speak about their thoughts, prep, and chances of winning their division’s world championship. There was occasional trash talking too, which entertained the fans even more.

The beginning of the press conference featured the trailer for the film “Dream Big,” which will document the Olympia and its impact on fitness and the world. It is set to be released to theaters and streaming platforms in 2025.

2024 Olympia Weekend Kicks Off With Annual Press Conference
Wings of Strength

Ladies First

The format was different this time around. Representatives for all six of the women’s divisions came out first at the Olympia 2024 Press Conference and took questions from bodybuilding insiders Fouad Abiad, John Romano, Dennis James, and Terrick El Guindy, as well as Hall of Famers Shawn Ray and Lenda Murray.

The ladies representing their divisions were Andrea Shaw, Angela Yeo, Sarah Villegas, Natalia Abraham Coelho, Missy Truscott, Taylor Learmont, Cydney Gillon, Jessica Reyes Padilla, Ashley Kaltwasser, Lauralie Chapados, Elisa Pecini, Angelica Teixeira, Francielle Mattos, Isabelle Nunes, Elisa Alcantara, and Eduarda Bezerra.

Four-time Ms. Olympia Shaw was the first to raise eyebrows when she vowed to redeem herself after she lost to Yeo at the 2024 Rising Phoenix. Shaw shared that she stayed in Arizona for seven weeks and changed coaches to make the changes she felt were necessary to redeem herself. For extra motivation, she had Bob Cicherillo announce “and five-time Olympia champion.”

“Conditioning will not be an issue for me this time,” she declared. Yeo was respectable yet determined to convey she was ready to prove herself worthy of the Olympia crown.

“She put seven weeks of work in. This has been years of work for me. I will be better than I was at the Rising Phoenix.”

One of the most inspiring stories of the year is Truscott’s return to the stage after her injury she suffered at the 2023 Olympia. She was excited and proud to get back onstage, but she is here for a reason – to win.

“I put everything into the rehab process. I had a goal in mind.”

We are guaranteed a new Bikini Olympia champion thanks to Jennifer Dorie opting to not compete this year. Kaltwasser has won three titles, and she has her sights set on a fourth as well as her own level of history, 50 career wins, extending her own record.

“Every year I get a little better,” she said. “If I win, it would be 50 on the 60th.”

There were some fun exchanges between the top Wellness competitors as well. Three-time Olympia champion Mattos sat next to top contenders Nunes. Alcantara Bezerra, all of whom were saying they were the future of the division. Mattos shut down that talk immediately,

“You are the future, but I am the present, and I am still here.”

Men Take Their Turns

Next up at the Olympia 2024 Press Conference were the men. Those on that panel included Derek Lunsford, Hadi Choopan, Brandon Curry, Andrew Jacked, Samson Dauda, Shaun Clarida, Keone Pearson, Chris Bumstead, Wesley Vissers, Ramon Rocha Querioz, Urs Kalecinski, Ryan Terry, Erin Banks, Harold Kelley, and Karol Milewski.

The last two Mr. Olympia champions, Lunsford and Choopan both think they will leave Las Vegas with the Golden Sandow Trophy in recognition of the 60th Olympia. Lunsford made his game plan known immediately – his back poses will serve him well.

“Lights out from the back, baby!”

Choopan countered by simply saying this will be the best version of his physique to date. Samson Dauda and Andrew Jacked were both making their size and presences known just by sitting in the chairs. Jacked’s statement was straight to the point.

“There will be some hearts breaking this weekend.”

Almost no one has spoken about Curry’s chances, and he was appreciative of the silence.

“Being quiet and off the radar helps me bring the shock factor. I will be ready to rumble.”

The line of the press conference may have been uttered by five-time Classic Physique Olympia champion. Bumstead was not only confident in his chances, but feels his opponents are not as confident in theirs.

“They all say they will win, but I look in their eyes, and I don’t think even they believe it,” he stated with a loud cheer from the crowd. “They are all fighting for second place.”

Ramon Rocha Querioz, who has improved his English this year, immediately reaffirmed his own confidence to win in 2024.

“It’s over for you.”

The action all begins on Friday, Mar. 11th with the Prejudging rounds for Fitness, 212, Figure, Women’s Physique, Ms. Olympia, and Wellness at the Las Vegas Convention Center.

If you are not in Las Vegas, head over to olympiaproductions.com to order the 2024 Olympia pay-per-view so you can catch all the action live as it happens.

David and Dudley

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David and Dudley

David and Dudley

As one of the most iconic pieces of art, Michelangelo’s David has come in for more than its fair share of criticism. It’s head’s too big, its hands are too big, its eyes are squint. One american school teacher ended up having to resign after showing a picture of the masterpiece to his class as it was considered pornographic.

Michelangelo, along with other artists of his time, quite often exaggerated aspects of their art to make a point. We have some sculptures that leave us wondering what exactly that muscle is that is protruding from their shoulder. Is it a rare anatomical variation or was it just the artist giving his hero more muscles?

When we look at David, we need to remember it was designed to be viewed from a long way below. It was originally planned to be on a roof top and not down in the piazza at eye level – well as much as anything that is 17 foot tall can be at eye level.

To ensure that artistic vanishing points didn’t make his sculpture look out of proportion when viewed from several storeys below, Michelangelo had to ensure that parts of the statue that are going to be closer to you were smaller and parts that were further away (the head) were larger.

What that doesn’t explain is an interesting anatomical variation that is almost completely overlooked. David’s second toe is longer than his big toe.

This variation is now called Morton’s toe after Dr Dudley Morton who studied the phenomenon in the 1930’s. Before that it was referred to as Greek Toe.

The Greek had a theory about a Golden Ratio which could be found through out nature. The concept was developed by Euclid in 300 BC who basically invented geometry. This longer second toe was a signifier of beauty and set them apart from the Romans and Egyptians.

Once the idea of the golden ratio became more prevalent, Morton’s toe started appearing in more art. It can be found in works of art by Sandro Botticelli and the Statue of Liberty feet also show a longer second toe.

People who read feet (yes that’s a thing) have nothing bad to say about Morton’s Toe so if you are one of the 25% of the population who have this variation then consider yourself blessed with some ancient Greek claim to splendor and enjoy your day.

Author: Anatomy Fundamentals

Janet Philp has spent a lifetime exploring fitness and wellbeing. Starting in group exercise, travelling through rugby to representing the UK at martial arts before including Yoga, meditation, Budokon and personal instruction. Her passion is anatomical function and educating people to use their bodies to their full potential.
View all posts by Anatomy Fundamentals

The Belt and Your Training

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The Belt and Your Training

The Belt and Your Training

by Mark Rippetoe | October 14, 2024

The Belt and Your Training

The function of the belt was
detailed in a previous article on this website. Used properly, it reinforces
the stiffness of the spine under a load. And to the extent that all
the lifts depend on force transfer through the spine, the belt helps
with efficiency in the lift while protecting the spine from wiggling
around under compression.

Here
are a few random thoughts about the belt and the lifts. Feel free to
add to it in the comments.

Most
people associate the belt with the deadlift and the squat, and it
certainly benefits these two movements by producing a hoop-tension
reinforcement around the spine over and above what the abdominal
musculature can provide. But the truth is that the press benefits
more from the belt than any of the other barbell lifts. The bench
benefits too, but this requires some experience with the set-up and
the timing. A shitty flexible belt works just fine for the bench
press – it’s not supporting your compressively loaded spine
anyway, and it’s easier to tighten while sitting on the bench (if you
don’t use the rack uprights).

The
Olympic lifts benefit as well, but the buckle can get in the way of
an efficient, close pull, and most lifters will turn the belt around
so that the buckle is on the low back, or use a Velcro belt that
doesn’t get in the way of the pull. The first time you catch the bar
under the buckle in a pull will be a memorable experience, and you
will alter your behavior accordingly.

As
mention in the linked article, a 3-inch belt works far better for
most people than a 4-inch, unless you are unusually long-waisted. I
prefer a smooth-leather belt, because it slides into tightness easier
than a nappy suede belt, but this is largely a matter of personal
preference. The suede is usually a thin piece of leather veneer, that
will eventually wear out before the rest of the belt, but some people
like the way suede grips the shirt. I think the primary effect of the
belt comes from the compression of the hoop tension, not the “grab.”
So our two-ply smooth leather Starting Strength belt from Dominion
Strength Training is always my recommendation for people wanting to
upgrade.

Don’t
get a cheap shitty belt to save money. A cheap buckle without a solid
roller will not last as long as the leather. A cheap buckle with a
skinny pin can actually cut through the belt, especially if the
leather is cheap or thin. This problem is solved with a 2-pin buckle,
with only half the force applied to each hole in the belt. But a good
belt with decent leather and correctly punched holes will not suffer
this fate. And two pins are harder to manage if you’re in a hurry to
get your belt on.

You
should not have to buy a belt more than once, because a good one will
not wear out or break. Your belt and your lifting shoes are the most
important pieces of your training equipment, so invest in quality and
take care of them. Lift in junk only for as long as it takes to save
up for good equipment, and you don’t have to buy it all at once.
You’ll be surprised at the difference it makes under the bar.

There
is a reason to have a single-ply belt: they are more flexible across
their width than a double ply, making it conform to the shape of your
waist better than a stiffer belt. This problem is largely solved by
the 3-inch width, and is probably a moot point in 2024, with modern
access to the latest developments in 3-inch belt technology. But I
promised random thoughts.

I
am always puzzled when I see a lifter finish a set and immediately
take the belt off and throw it on the platform, like they’re spiking
the ball. Why do this? It’s now a trip hazard on the floor, and you
just have to pick it up to put it back on. Why not just loosen it and
wear the damn thing between sets, to keep your back warm? I put the
belt on at 135, loosely, and make it tighter as the weight increases.
The first time you hurt your back – and you will, eventually,
everybody does – every loaded set thereafter should be belted. I
take it off after the last set.

Learn
to use the rack uprights to tighten the belt. Bend the tongue around
the upright C-channel and lean back to pull the belt through the
roller buckle until it’s as tight as it needs to be. Avoid wearing it
so tight that you cannot set your abs after your valsalva – this is
certainly possible with one hole too far. If in doubt, wear it one
hole looser rather than one hole too tight.

This
is all I could think of on short notice. Feel free to add your own
wisdom to the discussion in the comments.


Discuss in Forums

New! The Summer Shred Program

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Tom Myers on Gil Hedley’s Nerve Tour

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Tom Myers on Gil Hedley’s Nerve Tour

It was a great pleasure to attend Gil Hedley’s Nerve Tour in Portland, Maine, last night. With his characteristic flair, Gil unfolds a complete anatomy of our neural net, woven with a unique and touching story of ‘Captain’ – the model for much of the project – and the involvement of his family and other ‘friends of Gil’ in this labor of love. Really sweetly done, and totally unusual, as most times you have no notion about the personal lives of those who donate.

As a sometime dissector, I know how much labor and thought was involved in recreating that old osteopathic venture of laying the whole system on a lacquered board.

Tom Myers on Gil Hedley’s Nerve Tour
Credit: Andrew Taylor Still University

Gil is patient and entertaining in his presentation, but clearly determined to get you to see the whole picture, and relate the ‘onion tree’ of the neural net to life. The moment at the end where he holds the whole nervous system by the brain and sacral plexus – almost like Michelangelo’s Pieta in the Vatican – moves one to tears.

 

Gil and I go back more than 30 years. I was his first anatomy teacher, to my credit, but he has so far surpassed my anatomical knowledge that I was both informed and inspired by his care, compassion, and fierce dedication to stick to what he can see.

You can spend a lot worse afternoons than moving your rear end off the phone to go see this presentation live.
Probably coming to a venue near you – he’s in the middle of a 111-city tour.

Learn more about Gil Hedley’s Nerve Tour here.